Intrauterine Insemination (IUI)

Dr. Douglas may suggest intrauterine insemination for a variety of reasons, but the most common is male factor infertility. If problems exist with the sperm count, sperm motility, or sperm morphology, assisting the sperm in reaching the egg can offer a successful, yet relatively inexpensive treatment to consider. If your partner has a mild or moderate abnormality with any of these sperm factors, then timed intrauterine insemination is another good option treatment. With the IUI procedure, 5-10 times the number of sperm will reach the egg compared to intercourse.

Intrauterine insemination (IUI) is a procedure where sperm is placed directly inside the woman's uterus to increase the chance that the sperm and egg will meet. We usually combine the IUI procedure with ovulation induction medication to increase the chance of success, but in cases where a sperm issue is the only problem regular cycle IUI is also an option.


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For the IUI process, sperm is collected by ejaculation, or patients can use donor sperm if the sperm sample is extremely poor. Dr. Douglas advises the male partner to avoid ejaculation for two to six days before collecting the sample. Alternative methods are available for collecting sperm if the male partner is unable to ejaculate into a sterile container for religious or other reasons. One method is to use a special condom during intercourse that collects the sperm.

The laboratory then separates the active sperm from the inactive sperm, dead cells, and seminal fluid. The process of preparing sperm for IUI is similar to the sperm preparation process used in IVF procedures.

The timing of the IUI procedure can coincide with normal ovulation in a woman’s cycle, or Dr. Douglas can utilize a “trigger shot” to cause ovulation in a stimulation cycle. An ovulation kit can track normal ovulation. Once ovulation is indicated or the HCG, trigger shot is given, Dr. Douglas will schedule your IUI procedure.

During the IUI, a speculum is inserted in the vagina, similar to the kind used for an annual Pap. Next, Dr. Douglas places a long, thin, flexible tube through the vagina, across the cervix, and into the uterus to insert the prepared sperm sample. This procedure is painless, usually causing only a small amount of cramping, which resolves quickly after the procedure. The entire process takes less than five minutes to complete. After the insemination, you will need to lie down for approximately 5 minutes, but can then resume normal activities.

Complications with IUIs are uncommon, but cramping, light bleeding, and vaginal discharge may occur. Rarely, infection can occur that can cause a fever and pain. If this occurs it is important to call the doctor.

If IUI is not successful, a couple may choose to undergo in vitro fertilization (IVF) as a next step.